map from "[The Book of Ser Marco Polo, the Venetian, concerning the kingdoms and marvels of the East. Newly translated and edited, with notes, by H. Yule, ... With maps and other illustrations.]"

The Mediterranean Sea was the hub of transport, trade and cultural links between three continents: Western Asia, North Africa, and Southern Europe. The history of the cultures and people of the Mediterranean region is important for understanding the origin and development of the Mesopotamian, Egyptian, Canaanite, Phoenician, Hebrew, Carthaginian, Greek, Roman, Byzantine, Arab, Ottoman, Christian and Islamic cultures. The Italian "Repubbliche Marinare" (Maritime Republics) of Venice, Genoa, Amalfi and Pisa developed their own "empires" in the Mediterranean shores. The Islamic states had never been major naval powers, and trade from the east to Europe was soon in the hands of Italian traders, especially the Genoese and the Venetians, who profited immensely from it. The Republic of Pisa and later the Republic of Ragusa used diplomacy to further trade and maintained a libertarian approach in civil matters to further sentiment in its inhabitants. The republic of Venice got to dominate the eastern Mediterranean shores after the Fourth Crusade. In 1347 the Black Death spread from Constantinople across the mediterranean basin. In 1453, the Byzantine Empire was extinguished with the fall of Constantinople.