The Neurolab payload for STS-90, scheduled to launch aboard the Shuttle Columbia from Kennedy Space Center (KSC) on April 2, 1998, is moved to its workstand in the Operations and Checkout Building at KSC. Investigations during the Neurolab mission will focus on the effects of microgravity on the nervous system. Specifically, experiments will study the adaptation of the vestibular system, the central nervous system, and the pathways that control the ability to sense location in the absence of gravity, as well as the effect of microgravity on a developing nervous system. The crew of STS-90 will include Commander Richard Searfoss, Pilot Scott Altman, Mission Specialists Richard Linnehan, Dafydd (Dave) Williams, M.D., and Kathryn (Kay) Hire, and Payload Specialists Jay Buckey, M.D., and James Pawelczyk, Ph.D KSC-97PC1714

The Space Shuttle program was the United States government's manned launch vehicle program from 1981 to 2011, administered by NASA and officially beginning in 1972. The Space Shuttle system—composed of an orbiter launched with two reusable solid rocket boosters and a disposable external fuel tank— carried up to eight astronauts and up to 50,000 lb (23,000 kg) of payload into low Earth orbit (LEO). When its mission was complete, the orbiter would re-enter the Earth's atmosphere and lands as a glider. Although the concept had been explored since the late 1960s, the program formally commenced in 1972 and was the focus of NASA's manned operations after the final Apollo and Skylab flights in the mid-1970s. It started with the launch of the first shuttle Columbia on April 12, 1981, on STS-1. and finished with its last mission, STS-135 flown by Atlantis, in July 2011.